![]() ![]() We have two peptide based 3D scaffolds for cell culture and regenerative medicine, Proliferate and Trabeculate. The process allows for the manufacture of 3-D structures in practically any polymer including biodegradable, biocompatible, organic or inorganic. This novel process allows for a more precisely controlled pore structure, pore volume and pore dimension that could not previously be achieved. Generally a more workable pore size would be in the range of 40-200um and the ability to create a specific pore size within this range is probably the ultimate goal for tissue engineers.Īt Spheritech we have invented a process for the manufacture of super-macroporous polymer scaffolds for cell culture. An optimum scaffold will have carefully engineered pores designed for cell type and rate of migration. ![]() Ideally a super-macroporous structure is required which allows efficient migration of nutrients and waste but importantly allows rapid and unhindered diffusion of cells. The macroporous scaffold’s utilized to-date have poorly defined pore structure and the pores are generally either too small or have broad pore size distribution. The porosity and properties under flow are crucial factors to consider when designing macroporous structures. The scaffold must firstly allow cell attachment and migration, enable diffusion of cell nutrients and expressed waste and provide the requisite mechanical and biological properties. These structures, usually referred to as scaffolds, are critical for allowing cells to influence their own micro environments both ex-vivo and in-vivo. In order to culture and differentiate cells in three dimensions it is necessary to seed cells into an artificial structure capable of supporting tissue formation. 3-Dimensional Scaffolds for Regenerative Medicine ![]()
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